- GUTRON is used to treat the symptoms of idiopathic orthostatic hypotension found in Bradbury-Eggleston or Shy-Drager syndromes. Idiopathic orthostatic hypotension is a fall in blood pressure that occurs upon rising abruptly to an upright position although it may also occur following a period of prolonged standing.
- The body's nervous system is responsible for this type of hypotension. GUTRON is administered in those cases where the response to other therapy is not adequate.
- GUTRON is also used where hypotension is a consequence of other medical disorders such as diabetes or Parkinson's disease.
- Hypotension is low blood pressure . It is a measure of the blood pressing on the artery walls. This pressure helps move your blood around your body. You have hypotension when your blood pressure stays lower than normal. GUTRON may increase your blood pressure by constricting the walls of your blood vessels.
- Your doctor may have prescribed GUTRON tablets for another reason.
- Ask your doctor if you have any questions about why GUTRON tablets have been prescribed for you.
- GUTRON tablets are a prescription only medicine.

When the Need is Fast and Effective Control in your Arrhythmia Patients
MEXOHAR ® (mexiletine hydrochloride) is an orally active antiarrhythmic agent available as 50 mg and 150 mg capsules and 250 mg injection. 100 mg of mexiletine hydrochloride is equivalent to 83.31 mg of mexiletine base. It is a white to off-white crystalline powder with slightly bitter taste, freely soluble in water and in alcohol. MEXOHAR has a pKa of 9.2.
MEXOHAR (mexiletine hydrochloride) is a local anesthetic, antiarrhythmic agent, structurally similar to lidocaine, but orally active. In animal studies, MEXOHAR has been shown to be effective in the suppression of induced ventricular arrhythmias, including those induced by glycoside toxicity and coronary artery ligation. MEXOHAR, like lidocaine, inhibits the inward sodium current, thus reducing the rate of rise of the action potential, Phase 0. MEXOHAR decreased the effective refractory period (ERP) in Purkinje fibers. The decrease in ERP was of lesser magnitude than the decrease in action potential duration (APD), with a resulting increase in the ERP/APD ratio.